منابع مشابه
Dystrophic muscles get overexcited
Without the SNF-6 acetylcholine transporter (bottom) mutant muscles fall apart. K im /M ac m ill an they are mutant for various members of the dystrophinglycoprotein complex (DGC), which links intracellular actin to extracellular laminin. But now, Hongkyun Kim, Steven McIntire (University of California, San Francisco, CA), and colleagues suggest that loss of the DGC results in loss of an associ...
متن کاملHormonal Receptors in Skeletal Muscles of Dystrophic Mdx Mice
INTRODUCTION Several evidences show that muscles have an endocrine function. Glucocorticoid, estrogen, progesterone, and testosterone receptors have already been found in normal skeletal muscles, but not in dystrophic muscles. METHODS The gene expression of hormone receptors was compared between dystrophic and healthy muscles in mdx and C57BL6 mice strains. RESULTS The mdx mice showed a sig...
متن کاملHyperthermic seizures and aberrant cellular homeostasis in Drosophila dystrophic muscles
In humans, mutations in the Dystrophin Glycoprotein Complex (DGC) cause muscular dystrophies (MDs) that are associated with muscle loss, seizures and brain abnormalities leading to early death. Using Drosophila as a model to study MD we have found that loss of Dystrophin (Dys) during development leads to heat-sensitive abnormal muscle contractions that are repressed by mutations in Dys's bindin...
متن کاملNovel insight into stem cell trafficking in dystrophic muscles
Recently published reports have described possible cellular therapy approaches to regenerate muscle tissues using arterial route delivery. However, the kinetic of distribution of these migratory stem cells within injected animal muscular dystrophy models is unknown. Using living X-ray computed microtomography, we established that intra-arterially injected stem cells traffic to multiple muscle t...
متن کاملThe Functional Status of Dystrophic Muscles and Functional Recovery by Skeletal Muscles Following Myoblast Transfer
The diversity of movement in mammals requires three different types of muscle contraction: isometric (fixed end), miometric (shortening), and pliometric (lengthening). Consequently, an adequate evaluation of the functional status of dystrophic muscles and of the recovery of dystrophic muscles after myoblast transfer requires measurements during each type of contraction. Although subject to some...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1666rr3